If coadministration of CYP3A4 inhibitors with fentanyl is important, watch patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose changes until eventually stable drug effects are obtained.
Watch Carefully (one)enasidenib will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
If coadministration of CYP3A4 inhibitors with fentanyl is necessary, monitor patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose changes until eventually stable drug effects are realized.
fentanyl iontophoretic transdermal system and fentanyl both maximize sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom choice treatment options are insufficient
Monitor Carefully (1)somapacitan will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
ketoconazole will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Observe for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments till stable drug effects are achieved.
nevirapine will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a decrease in fentanyl plasma concentrations, not enough efficacy or, probably, growth of a withdrawal syndrome in a very affected person that has made Bodily dependence to fentanyl.
You are going to typically only use fentanyl tablets, lozenges or nasal spray when you will need them. Notify your doctor if you might want to utilize them far more than four times on a daily basis.
Check Intently (1)lonapegsomatropin will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
somapacitan will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
If coadministration of CYP3A4 inhibitors with fentanyl is essential, keep track of patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments right up until stable drug effects are reached.
lasmiditan, fentanyl. Both increases effects with the other by sedation. Use Warning/Keep an eye on. Coadministration of lasmiditan and other CNS depressant drugs, including Alcoholic beverages haven't been evaluated in clinical studies. Lasmiditan might cause sedation, in addition fentanyl adverse effects to other cognitive and/or neuropsychiatric adverse reactions.
fentanyl will raise the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Lower nightly dose of lemborexant encouraged if coadministered with weak CYP3A4 inhibitors. See drug monograph for distinct dosage modification.
If coadministration of CYP3A4 inhibitors with fentanyl is important, monitor patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose changes till stable drug effects are realized.